Long term potentiation, but not depression, in interlamellar hippocampus CA1
نویسندگان
چکیده
منابع مشابه
Long-term potentiation in the CA1 hippocampus.
This reinforces the view (9) that the simple relations of quantal analysis do not necessarily hold in heterogeneous populations such as those found in the central nervous system. Addition of synapses with lower quantal size will, however, change the amplitude distribution of nonfailure responses, which was not observed in the above studies (1, 2). Nevertheless, detecting this change in distribu...
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One major theory in learning and memory posits that the NR2B gene is a universal genetic factor that acts as rate-limiting molecule in controlling the optimal NMDA receptor's coincidence-detection property and subsequent learning and memory function across multiple animal species. If so, can memory function be enhanced via transgenic overexpression of NR2B in another species other than the prev...
متن کاملInterlamellar CA1 network in the hippocampus.
To understand the cellular basis of learning and memory, the neurophysiology of the hippocampus has been largely examined in thin transverse slice preparations. However, the synaptic architecture along the longitudinal septo-temporal axis perpendicular to the transverse projections in CA1 is largely unknown, despite its potential significance for understanding the information processing carried...
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introduction: generally, nmda receptor antagonists inhibit learning and long-term potentiation (ltp). however, it has been suggested that direct tonic activation of nmda receptors, in contrast to learning, may lead to an increase in synaptic “noise”. uncompetitive nmda receptor antagonist memantine can paradoxically reverse deficits in learning and synaptic plasticity, and restore ltp impaired ...
متن کاملNitric oxide facilitates long-term potentiation, but not long-term depression.
Reports that nitric oxide synthase (NOS) inhibition prevents the induction of long-term potentiation (LTP) have been controversial. Recent evidence suggests that NO may help to regulate the threshold for LTP induction. We have tested this hypothesis by examining the effects of stimulus frequency and train duration on synaptic plasticity in the presence of either NO donors or NOS inhibitors. Two...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-23369-4